Optical Monitoring of the Generation of Singlet Oxygen during Photodynamic Treatment of Tumors
نویسنده
چکیده
Research at APL has been directed at understanding energy transfer events taking place after laser excitation of photosensitive compounds in condensed media. In particular, optical means have been developed for the detection of electronically excited molecular oxygen (singlet oxygen) resulting from a favored energy transfer from the sensitizer triplet state. Oxygen excited in this manner is thought to playa key role in a new means for treating certain types of cancer. Recently at APL, small-animal experiments were conducted in which singlet oxygen generation was detected in laser-irradiated, presensitized, small-animal tumors.
منابع مشابه
A Singlet Molecular Oxygen Imaging Sensor for Photodynamic Therapy
Singlet oxygen is believed to be the species destroying cancerous cells during PDT. An optically-based imaging device for monitoring singlet oxygen production in a tumor was developed and tested in-vivo. ©2008 Optical Society of America OCIS codes: (170.0110) Imaging systems; (170.5180) Photodynamic therapy
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